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Inducing fibrogenesis and new interfibrillary bonds in post-LASIK ectasia was previously reported as new treatment for ectasia aiming for the reintegration of the created LASIK flap into the residual corneal stroma in ectatic corneas. The aim of this study is to evaluate the long term safety and efficacy of this technique (up to 1 year follow up)
This is a prospective study of patients who were treated with fibrogenesis for iatrogenic corneal ectasia after LASIK surgery. The Fibrogenesis technique is described elsewhere by Jarae et al. Patients were closely followed up up to 1 year. Slit lamp exam, Uncorrected distance visual acuity (UCDVA), Corrected distance visual acuity (CDVA), manifest refraction and corneal tomography maps were recorded at baseline, 6 months and 1 year post treatment. The Keratometry readings and corneal thickness were obtained using Pentacam Scheimpflug imaging the WaveLight® Allegro Oculyzer™ (WaveLight, GmbH, Erlangen, Germany). results, complications and patient's satisfactions were all recorded
22 eyes with post-LASIK ectasia who underwent the procedure were included. At 6 months there was a statistically significant reduction in SE by 1.26 ±1.79 D; p= 0.003, and a small increase in mean central corneal thickness (CCT) by 8.68 ± 19.43; p= 0.048. K-mean remained stable. At 1 year,there is reduction in SE from baseline by 1.08 ± 2.15 D; p=0.032 and there was also a statistically significant decrease of K-mean by 1.34 ± 1.96 D; p=0.004. However, the improvement in mean CCT was no longer present. CDVA, cylinders and K max remained stable. UCDVA has had a trend to improve without reaching a statistically significant level. No complications were noted up to one year Follow up
Up to one year follow-up, Inducing fibrogenesis and new interfibrillary bonds is considered as safe and effective new treatment for post LASIK ectasia. Primary data suggests an improvement from baseline in spherical error and K-mean. Those findings need to be consolidated, in the future, by a larger sample size and a longer follow up period