PDEK: Is It Any Better Than DMEK? | ASCRS
Poster
PDEK: Is It Any Better Than DMEK?
May 2019
Meeting: 2019 Annual Meeting
Author: Rachel Epstein, MD; Parag Majmudar, MD
Poster ID: 51814
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Poster Abstract

Purpose
To evaluate an emerging lamellar keratoplasty technique, Pre-descemet’s endothelial keratoplasty (PDEK), versus our accepted technique Descemet Membrane Endothelial Keratoplasty (DMEK) for the treatment of Fuchs corneal dystrophy.
Methods
A retrospective review of 10 consecutive DMEK and 10 PDEK procedures performed by a single surgeon at a single center using pre-stripped and preloaded tissue provided by a single eyebank. Patients with endothelial dysfunction resulting from causes other than Fuchs corneal dystrophy as well as patients with prior ocular surgery other than cataract surgery were excluded to limit confounding variables. Complications in the first 3 months after surgery such as early graft failure or re-bubbling were recorded. Donor endothelial cell loss (ECL) and best corrected visual acuity (BCVA) were assessed at 3 months.
Results
Mean logMAR post-operative BCVA was 0.12 in the DMEK group and 0.14 in the PDEK group. There was no statistically significant difference between these groups (p = 0.1581, 95% CI [-0.3718 - 0.688]. Endothelial cell loss (ECL) was 25% in the DMEK group and 17% in the PDEK group. There was a 71% re-bubble rate in the DMEK group versus 42% in the PDEK group. There were no reports of primary graft failure in either group.
Conclusion
Mean logMAR post-operative BCVA was 0.159 in the DMEK group and 0.285 in the PDEK group. There was no statistically significant difference between these groups (p= 0.08378, CI (95%), -0.3147 - 0.0627). Endothelial cell loss (ECL) was 11% in the DMEK group and 7% in the PDEK group. There was a 50% re-bubble rate in the DMEK group versus 30% in the PDEK group. There was a single primary graft failure in the PDEK group.
Filed Under
Cornea PDEK DMEK

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